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KMID : 0605720110170010063
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Journal of the Korean Society of Biological Therapies in Psychiatry
2011 Volume.17 No. 1 p.63 ~ p.69
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Comparison of Laboratory Blood Test Markers in Patients with Mild Cognitive Impairment(MCI) and Alzheimer’s Disease(AD)
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Lee Dong-Ki
Kim Jeong-Gee
Kim Yang-Tae
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Abstract
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Objectives:The purpose of this study is to compare laboratory blood test markers in patients with mild cognitive impairment(MCI) and Alzheimer’s disease(AD) among elderly over the age of 65.
Methods:176 subjects who scored lower 1.5SD of the Korean version of Mini-Mental State Examination(MMSEKC) were evaluated using the Korean version of the Consortium to Establish a Registry for AD(CERAD-KC) and Clnical dementia Rating(CDR) and Global Deterioration Scale(GDS). 70 subjects scored over 0.5 in CDR and they were divided into two subgroups. 24 subjects was diagnosed with AD. And 40 subjects was diagnosed with MCI. We evaluated them with laboratory test and demographic factors.
Results:According to the demographic data, there was a correlation between old age/low level of education and AD. Regarding the laboratory findings of total cholesterol level and total bilirubin level. There were significant differences between Alzheimer’s disease and mild cognitive impairment(p＜0.05).
Conclusion:There were correlations between Alzheimer’s disease(AD) and high serum total cholesterol level/low serum total bilirubin level.
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KEYWORD
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Mild cognitive impairment, Alzheimer’s disease, Cholesterol, Bilirubin
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